Finding synonymous coding DNA sequences with maximum base pairing
Claudio Arbib  1@  , Andrea Manno  2@  , Fabrizio Rossi  3@  , Andrea D'ascenzo  2, *@  
1 : Università degli Studi dellÁquila [LÁquila]  (UNIVAQ.IT)  -  Website
Via Giovanni Di Vincenzo 16/B, 67100 LÁquila -  Italy
2 : Università degli Studi dell'Aquila
3 : Department of Information Engineering, Computer Science and Mathematics University of L'Aquila  -  Website
Università degli Studi dell'Aquila, Via Vetoio, I-67100 L'Aquila -  Italy
* : Corresponding author

A Coding DNA Sequence (CDS) is a sequence of bases that, organized into triplets (codons), encodes for a protein. As different codons can encode the same amino acid, the same protein is encoded by a very large number of CDSs and a problem arises of finding optimal CDSs with respect to given indicators. Here the Base Pairing Number is considered, the largest number of hydrogen bonds the bases can form in a feasible folding. We developed an implicit enumeration algorithm based on dynamic programming to maximize base pairing, and tested it on random and human genome CDSs. The method performs an effective reduction of the search space and turns out to be more efficient than integer programming to solve the problem.



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